CytoSorbents: A Quick Rebound Indicates Belief in Progress and Potential (CTSO)

CytoSorbents Corporation (OTCBB: CTSO) is a publicly-traded, critical care focused therapeutic device company using blood purification to treat life-threatening illnesses. Its purification technology is based on biocompatible, highly porous polymer beads that can actively remove toxic substances from blood and other bodily fluids by pore capture and surface adsorption. Each polymer bead contains millions of pores and channels that can be modified to remove substances as small as drugs, to substances as large as antibodies. 

At MarketPlayground.com, contributor VFC's StockHouse wrote an article analyzing the Company's recent share price drop and the possible reasons behind it.

He reminds investors,

"Cytosorbents is trucking along for a company its size and a technology that may be so good that doctors have to see it to believe it — and given that the European regulators were convinced to approve CytoSorb even before the final trial results were in, there’s a strong case to be made that the believers are out there."

He points out that in addition to moving forward with the commercial launch of CytoSorb, the Company is also making progress on other fronts, too: 

"The HemoDefend blood purification technology could help the company land a partner and lead to revenue while CytoSorb continues its roll-out, and the US Army has also jumped on board to support the company with the awarding of a grant late last year.

As those events unfold and pay dividends, 2012 could easily turn into another milestone year for CytoSorbents. The quick rebound from last week’s drop is a good indicator that there is a solid foundation of patient investors that believe the same and are willing to stick this one out."

 
Read more at MarketPlayground.com. 

CytoSorbents Publishes Responses to Frequently Asked Questions - May 2012 (CTSO)

CytoSorbents Corporation (OTC.BB: CTSO) is a critical care focused therapeutic device company using blood purification to modulate the immune system and fight multi-organ failure in life-threatening illnesses. Its purification technology is based on biocompatible, highly porous polymer beads that can actively remove toxic substances from blood and other bodily fluids by pore capture and adsorption.

The Company has prepared a list of Frequently Asked Questions ("FAQs") and responses in answer to a number of questions from shareholders on May 16, 2012. Other common inquiries are also included. 

The company provides detailed answers to the following questions:

• If there is so much interest in CytoSorb®, why are Q1 2012 sales low and why the decline from Q4 2011? 
• Why has it taken longer to hear news on things that were discussed in presentations or press releases months ago? 
• What are your thoughts about focus on Germany, versus expansion through distributors elsewhere? 
• What are the plans to publish the data from the European Sepsis Trial and can you give an update on the dosing study and other studies? Are the results of the dosing study needed to sell CytoSorb? 
• Are you contemplating manufacturing in Europe or utilizing a contract manufacturer? 
• There seems to be a lot of bashers on the stock message boards that post negative comments constantly, always trying to instill fear and doubt into shareholders who believe in the company. What can be done? 
• If there is so much potential in the company, why is your stock so low and what do you plan to do about it? 

Read the answers at CytoSorbents.com. 

At Seeking Alpha, Ampio Pharmaceuticals Follows Multiple Pipeline Strategies With Potential; $CTSO

CytoSorbents Corporation (OTCBB: CTSO) is a critical-care focused therapeutic device company using blood purification to treat life-threatening illnesses. These are common, major conditions seen in the intensive care unit (ICU), such as sepsis and infection, severe trauma, burns, lung injury, and pancreatitis, that afflicts millions of people each year yet lacks effective therapies, leading to a mortality rate that often exceeds 30%. Failure of multiple organs, such as the lungs, heart, kidneys and liver, is the leading causes of death from these conditions, for which very little can be done today. Hospital acquired infections are another leading cause of death in the ICU. CytoSorbents is developing novel and advanced blood purification therapies designed to actively prevent, mitigate, or reverse the development of organ failure and infection, thereby potentially reducing illness severity and helping patients to heal and recover faster. 

On Seeking Alpha, VFC's Stock House wrote an article discussing the reasons a company might choose to seek drug approval overseas before pursing the US market. In the case of Ampio Pharmaceuticals (AMPE), for example, "the reason why Ampio is not seeking a US approval for Zertane in the treatment of PE is quite simple - the FDA does not recognize the condition as a medical need." He noted that "Cytosorbents Inc. (CTSO) is another company that keyed in on Europe before setting sights on the US market."

He explained,

"There is little doubt that when it comes to making money in the pharmaceutical and health care industries, the US market is the place to be. Companies know that and investors thrive on making money based on that fact. That said, contrary to the belief of some, there is a whole wide world out there other than the United States, and in many cases it is cheaper to do business and conduct trials overseas than it is back home...

The more cautious investor may shy away from investing in a company that looks to see if a product works overseas first before then concentrating on the FDA in an effort to save a few dollars, but others may be attracted to a business model that might not leave a company as exposed to the loan shark financing deals that are prevalent in the US to keep the early stages of the pipeline going."

Read the full article at Seeking Alpha. 

CDC Report: Sepsis Hospitalizations Rates Double Across Last Decade, Driven by Elderly; $CTSO

CytoSorbents Corporation (OTCBB: CTSO) is a critical-care focused therapeutic device company using blood purification to treat life-threatening illnesses. These are common, major conditions seen in the intensive care unit (ICU), such as sepsis and infection, severe trauma, burns, lung injury, and pancreatitis, that afflicts millions of people each year yet lacks effective therapies, leading to a mortality rate that often exceeds 30%. Failure of multiple organs, such as the lungs, heart, kidneys and liver, is the leading causes of death from these conditions, for which very little can be done today. Hospital acquired infections are another leading cause of death in the ICU. CytoSorbents is developing novel and advanced blood purification therapies designed to actively prevent, mitigate, or reverse the development of organ failure and infection, thereby potentially reducing illness severity and helping patients to heal and recover faster. Ultimately the goal is to improve patient outcome and save healthcare costs. Nearly 1% of the US gross domestic product (GDP), or approximately $90 billion, is spent on critical care annually in the US, and billions of dollars are lost by hospitals each year due to a lack of effective therapies. 

Recently, the U.S. Centers of Disease Control and Prevention (CDC) published a report on the epidemiology of sepsis in the US after examining hospital admission data from 2000 to 2008 from the National Hospital Discharge Survey. According to the researchers, “the number of hospitalizations for sepsis more than doubled between 2000 and 2008, resulting in much longer, costlier hospital stays and more fatal outcomes”. The jump in sepsis rates were attributable to several factors, including the aging population, a rise in invasive procedures, and the increased use of catheters. Read more report highlights here. 

But in particular, the elderly were driving the statistics. Patients 65 and older:

1. Have other conditions that put them at high risk of infection such as diabetes, cancer, and implanted medical devices like artificial hips and knees.
2. Are driving the incidence of sepsis hospitalizations, recently accounting for two-thirds of all patients hospitalized with sepsis in the U.S.
3. Have a 13-fold relative risk of death compared to patients younger than age 65.
4. Are the ones dying of sepsis, predominantly from multi-organ failure and hospital acquired infections, rather than the original infection itself.

CEO of CytoSorbents Dr. Phillip Chan stated,

"Unfortunately, most of us know someone who has died from sepsis and other complications of serious infections like pneumonia, urinary tract infections, abdominal infections, and influenza. Although sepsis kills thousands of babies, children, teens, and young adults each year, it is unquestionable that older patients, particularly those 65 and older, have the highest risk of both developing a serious infection and dying from it. Despite antibiotics, approximately one-third of patients in the U.S. and Europe still die each year from severe sepsis each year, making it a top ten leading cause of death in the U.S. and elsewhere. And to make things worse, there are no available therapies in the U.S. or the European Union that are approved to specifically treat sepsis."

Dr. Chan continued,

"CytoSorbents has developed a blood purification therapy called CytoSorb™ that works with antibiotics, and targets the underlying fundamental reasons why people die of sepsis, which are multi-organ failure and additional infections. An inadvertent overproduction of cytokines, or ‘cytokine storm’, by the immune system is a key driver of the severe inflammation that then leads to cell death and organ failure, and a paralysis of the immune system. By reducing ‘cytokine storm’, CytoSorb™ aims to reduce or mitigate organ failure and additional infecitons, thereby helping patients to get better, faster. Based on data from our European Sepsis Trial, CytoSorb™ appears to have a unique protective effect on patients 65 and older, preventing death to 14 days. If we can extend this treatment benefit in future studies, CytoSorb™ has the potential to revolutionize not only sepsis treatment in this patient population, but other life-threatening illnesses where cytokine storm plays a deadly role."

CDC Sepsis Brief 2011

View more documents from CytoSorbents

ProActive Capital Resources Group Announces Client Participation at San Francisco Healthcare Conferences

JP Morgan's 30th Annual Healthcare Conference 

5^th Annual OneMedForum San Francisco 2012

Biotech Showcase 2012 in San Francisco

New York, NY, January 9, 2012 – ProActive Capital Resources Group, a strategic corporate communications, investor relations and social media firm today announced that several of its clients will be presenting at three prestigious investor conferences in San Francisco next week. The following companies will be presenting their corporate presentations at JP Morgan's 30th Annual Healthcare Conference, the 5^th Annual OneMedForum San Francisco 2012, and the Biotech Showcase 2012 in San Francisco.

“We are proud to have several of our clients presenting at these quality industry conferences as we continue to grow our healthcare practice at ProActive Capital,” stated Jeff Ramson, CEO of ProActive Capital Resources Group. “These healthcare conferences provide the visibility and help build awareness as our clients continue to execute on their growth initiatives.”

To schedule a one on one meeting with any of the companies please contact us at the number below.

Coronado Biosciences, Inc. (Nasdaq:CNDO), will present at the Biotech Showcase 2012 Conference on Wednesday, January 11, 2012 at 4:30 PM PT.

Ventrus BioSciences, Inc. (Nasdaq:VTUS) will be attending the conferences and is available for one on one meetings.

Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) will be presenting at JP Morgan's 30th Annual Healthcare Conference on Thursday, January 12, 2012 at 10:00 a.m. PT.

WaferGen Biosystems, Inc. (OTCBB:WGBS.OB) - The company is scheduled to present at OneMedForum on Tuesday, January 10, 2012 beginning at 10:00 a.m. PT.

Tonix Pharmaceuticals Holding Corp. (OTCBB:TNXP.OB), will be presenting at the Biotech Showcase 2012 on Monday, January 9, 2012 at 10:00 a.m. PT, as well as on Tuesday, January 10, 2012 at 10:15 a.m. PT at the OneMedForum Conference.

AtheroNova, (OTCQB: AHRO.OB) will be attending the conferences and is available for one on one meetings.

Fibrocell Science, Inc. (OTCBB:FCSC.OB), will be presenting at the 5^th Annual OneMedForum on Wednesday, January 11, 2012 at 10:00 a.m. PT.

Cerecor Inc. (a privately held company) will present at the Biotech Showcase 2012 on Monday, January 9th at 10:00 AM PST. 

NeoStem, Inc. (NYSE Amex: NBS) will be presenting at Biotech Showcase 2012 on January 10, 2012 at 10:30 a.m. PT.

CytoSorbents Corporation (OTC.BB: CTSO.OB), will present at the OneMedForum 2012 on Wednesday, January 11, 2012 at 11:15a.m. PT.

For more information about each of the conferences, go to:

www.onemedplace.com/forum/

http://www.ebdgroup.com/bts/index.php

About ProActive Capital Resources Group, LLC

ProActive Capital Resources Group, LLC (“PACRG”) (www.proactivecrg.com) is dedicated to the discovery and creation of value in the small-cap marketplace. PACRG provides turnkey solutions that combine traditional investor relations services with the latest Internet, mobile and social media communications. The Company’s integrated digital media and global distribution platform www.ProActiveNewsroom.com connects innovative, emerging-growth companies to the investment community using a variety of user-friendly and interactive formats.

Investor Relations Contact:

Jeff Ramson

Proactive Capital Resources Group, LLC.

212-792-4294

jramson@proactivecrg.com